In an application where I need to know that all data has been transmitted, a FT232R works, but Pl2303GT and PL2303TA do not. I tracked this down to a tcdrain() issue: If I add an usleep() calculated to give enough time to transmit everything, the PL2303GT and PL2303TA work too. So I had a quick look at the pl2303 driver. It sets port.drain_delay to 256, which should be enough to drain the buffers. However, it looks to me as if port.drain_delay is used only when closing the port (via tty_port_close in tty_port.c), not for tcdrain (via TCSBRK ioctl in tty_io.c).