My son built a new Ubuntu box from scratch dedicated to PyRosetta. He is able to install the Rosetta extensions and launch python to import the libraries without error. Per the PyRosetta instructions he then initializes via rosetta.init(). At this point the box locks up hard. All ssh sessions become unresponsive. He provided me with this from syslog: ihuntress27@twig:~/research$ sudo find /var/log -type f -print0 | xargs -0 sudo zgrep "rosetta" /var/log/auth.log:Binary file (standard input) matches /var/log/kern.log.1:Jun 26 21:35:52 twig kernel: [196475.974143] rosetta.so[5861]: segfault at 0 ip 000055ec90808eb1 sp 00007fffbd9d0778 error 4 in rosetta.so[55ec70a02000+38b63000] /var/log/apport.log.2.gz:ERROR: apport (pid 5862) Sun Jun 26 21:35:52 2016: executable: /home/ihuntress27/research/PyRosetta.monolith.ubuntu.release-103/rosetta.so (command line "./rosetta.so") This was repeated multiple times while troubleshooting. I expect this should be handled by the rosetta team, I was still surprised that it could elicit a hard lockup and that's why I'm reporting the crash.